H2BC21 and neoplasm: The mutations in this tumor included 3 predicted high impact mutations in MTOR a regulator of stress response, OGT a glycosyltransferase that modifies a broad range of targets including H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1, and FAM129B a negative regulator of apoptosis [19].