PIM3 and pancreatic neoplasm: For example, miR-182 promotes pancreatic cancer cell proliferation and migration by targeting beta-TrCP2 [8]; miR-940 promotes cell proliferation by targeting GSK3β and sFRP1 in human pancreatic carcinoma [9]; on the other hand, miR-34a inhibits pancreatic cancer progression via Snail1-mediated epithelial-mesenchymal transition and the notch signaling pathway [10]; miR-377 inhibits the proliferation of pancreatic cancer by targeting Pim-3 [11].