Human HOTAIR, is a 2.2 kb lncRNA transcribed from the HOXC locus and has been shown to bind both to the PRC2 and the LSD1 complexes and aberrant expression of HOTAIR has been associated with tumorigenesis in various types of cancers including breast cancer, colorectal cancer, lung cancer, gastric cancer [35–38]. This evidence concerns the gene KDM1A and colorectal cancer.