To analyze the effect of MG-2477 on the survival of neuroblastoma cells, we chose a set of cell lines that are derived from different tumor stages [31, 40] and vary in PKB expression and PKB activity (phosphoPKB/PKB ratio from 1.2 to 8.6, Supplementary Figure 1B) and MYCN status [56, 57]. The gene discussed is MYCN; the disease is neuroblastoma.