Comparing CovEx predictions to HotNet2 predictions, we found that some of the annotated cancer genes, e.g. BAP1, EGFR, ERBB4, KRAS, NRAS, WT1, etc. were identified by both CovEx and HotNet2 in the largest type 1 sub-network, while some of them, e.g. ABL1, AKT1, APC, RB1, etc. were identified only by CovEx. The gene discussed is APC; the disease is cancer.