Comparing CovEx predictions to HotNet2 predictions, we found that some of the annotated cancer genes, e.g. BAP1, EGFR, ERBB4, KRAS, NRAS, WT1, etc. were identified by both CovEx and HotNet2 in the largest type 1 sub-network, while some of them, e.g. ABL1, AKT1, APC, RB1, etc. were identified only by CovEx. This evidence concerns the gene AKT1 and cancer.