These discoveries are not only in agreement with the documented role of NFkB as a central mediator of TQ anti-cancer actions [38–41] and a direct/indirect regulator of DNA methylation [1, 2, 24, 28], but also support DNMT1-associated DNA methylation as a new pharmacological endpoint of leukemia cells in response to TQ exposure as well as a common molecular rule underlying phytochemical compound-mediated cell death. The gene discussed is DNMT1; the disease is cancer.