DNMT1 and cancer: This is because 1) aberrant DNA methylation is a well-documented hallmark of cancers [34–36], 2) the therapeutic effects from typical DNA hypomethylating agents are limited [8, 37], 3) our previous study revealed that phytochemical compounds, such as curcumin, inhibit DNA methylation [25], and TQ is a phytochemical compound, and 4) multiple investigations demonstrated that TQ executes anticancer actions largely through NFkB signaling [38–41], which functions as a upstream regulator for many genes, including DNMT1 [1, 2, 24].