WWTR1 and neoplasm: Hematoxylin and eosin (H&E) staining and immunohistochemical (IHC) analysis of tumor histology and TAZ expression, respectively showed that overexpression of TAZ-S89A in E10 lung epithelial cells stimulates tumor formation characterized by high-grade poorly differentiated carcinoma with high nuclear (activated) TAZ expression (Figure 1A).