This conclusion is supported by several lines of evidence, including the upregulation of ERRF by lapatinib in lapatinib-sensitive SK-BR-3 and BT-474 breast cancer cell lines (Figure 1A–1C), downregulation of ERRF in lapatinib-resistant clones derived from SK-BR-3 and BT-474 cells (Figure 1D) [44], and the association of ERRF expression with lapatinib sensitivities in breast cancer cell lines (Figure 1E) [44]. This evidence concerns the gene SRARP and breast carcinoma.