Moreover, candidates can be impacted by SNPs in “GATA” motif in their regulatory elements, as direct downstream targets of GATA3, such as rs4894953, located in the enhancer region of CBLB, appears in the C allele, then expression of CBLB is down-regulated compared with T allele as the result of losing GATA3 binding site characterized in CBLB. Some of the other candidates have been linked to GATA3 through PPI prediction, and the validations for well-known cancer related genes should be first priority to reveal the mechanism of GATA3 induced leukemogenesis. The gene discussed is CBLB; the disease is cancer.