STAT4 and acute lymphoblastic leukemia: Taking STAT4 as an example, which is positively related to GATA3 expression in healthy bone marrow (P = 5.7 × 10−21, and r2 = 0.7), the association got weak gradually in CLL (P = 4.7 × 10−78, and r2 = 0.54), CML (P = 1.2 × 10−10, and r2 = 0.42), AML (P = 1.2 × 10−23, and r2 = 0.17), B-ALL (P = 1.7 × 10−23, and r2 = 0.16), and T-ALL (P = 0.16, and r2 = 0.005) (Supplementary Table 4), and even negatively related to GATA3 expression in breast cancer (P = 1.2 × 10−66, and r2 = 0.14) (Supplementary Table 5).