Through a series of independent genome-wide association studies (GWAS) in ethnic diverse populations, several risk loci for ALL susceptibility have been identified (e.g., ARID5B, IKZF1, CEBPE, PIP4K2A, CDKN2A, GATA3) [3–10], and validated by subsequent replication studies [11–14]. Here, PIP4K2A is linked to acute lymphoblastic leukemia.