Interestingly, multiple GWASs revealed strong association of GATA3 SNP with ALL susceptibility, especially in Ph-like subtypes, and the risk allele of the top GWAS SNP is related to higher expression of GATA3. Therefore, the mechanism of how GATA3 involved in B lineage leukemogenesis can be studied on its upstream and downstream signals in leukemia cells from B-ALL patients. This evidence concerns the gene GATA3 and acute lymphoblastic leukemia.