Through genotyping of three tag missense variants on BRCA1/2 in 603 Chinese pancreatic cancer patients, we discovered the prognostic value of rs1799966 (c.4837A>G [p.Ser1613Gly]) on BRCA1. Further stratification analyses showed that the association was particularly in patients with local advanced stage, but not patients in local or metastatic stage. Here, BRCA1 is linked to familial pancreatic carcinoma.