For example, in adults with B-cell ALL increased CTGF (connective tissue growth factor) and LEF1 (lymphoid enhancer binding factor-1) expression are associated with worse RFS [6, 7] whereas increased BAALC (brain and acute leukemia, cytoplasmic) expression is associated with an unfavorable response to chemotherapy and worse survival [8]. The gene discussed is CCN2; the disease is acute leukemia.