Many HCC patients expressed high levels of the three tested proteins; specifically, high cyclin D1 was related to high pSmad2/3 expression (Figure 2D, asterisk on the top), high cyclin D1 was related to high Smad4 expression (Figure 2D, asterisk at the bottom), and high cyclin D1 expression was related to both high pSmad2/3 and Smad4 expression (Figure 2D, patients 1669T, 1834T, 2364T, 1454T, 1502T, 1524T, and 1574T). Here, CCND1 is linked to hepatocellular carcinoma.