Based on a linear regression analysis, 52.5% of HCC patients displayed significant cyclin D1-dependent pSmad2/3 expression (Figure 2E, Supplementary Figure 2C), and 55% of patients exhibited cyclin D1-dependent Smad4 expression (Figure 2F, Supplementary Figure 2D). The gene discussed is SMAD4; the disease is hepatocellular carcinoma.