The study by Schleckeret al., demonstrated that tumor cells release B7-H6, the ligand for the activating NK-cell receptor NKp30, by ectodomain shedding, resulting in reduced surface level of its expression on tumor cells and subsequently reduced NKp30-mediated recognition by NK cells, and thus helping tumor cells escape NK cell mediated killing [6]. Here, KLRD1 is linked to neoplasm.