When compared with JAK2V617F-mutated and TN ET patients, CALR mutations correlated with significantly lower serum BAFF level (median 1.6 ng/mL, p = 0.049) (Figure 1A) and higher fraction of B cells with TLR4 expression (median 11.3%, p = 0.021) (Figure 2A). This evidence concerns the gene TLR4 and essential thrombocythemia.