Herein, the aim of this meta-analysis is to provide a reliable estimation of the association of five common PDCD1 polymorphisms (PD1.1, PD1.2, PD1.3, PD1.5 and PD1.6) with SLE risk by combining original data from relevant primary studies and achieve a more comprehensive evaluation. This evidence concerns the gene PDCD1 and systemic lupus erythematosus.