Adsay et al. examined mass-forming (≥ 1 cm) pre-invasive neoplasms of the gallbladder and found that these tumors exhibited a spectrum of dysplastic changes, variable configuration, and different levels of MUCs, CKs, and CDX2 expression in different cell lineages, which resembled the presentation of IPNB [9]. Here, CDX2 is linked to neoplasm.