PTEN and cancer: This association held also true with high significance (p < 0.0001) in most subgroups of cancers with identical Gleason grade (≤ 3 + 3; 3 + 4; 4 + 3; ≥ 4 + 4;), and was independent of the ERG status (p < 0.0001), or presence of PTEN deletions (p = 0.0002) (Table 2).