In addition, the executive step in BER process that is controlled by WRN and its co-factor PNK kinase is most probably inactive, because both WRN and PNK kinase are deregulated at the expression level and mutated in Ovarian Serous Cystadenocarcinoma (Figure 5F), but not in Adenocortical Carcinoma (Figure 5C). The gene discussed is WRN; the disease is ovarian serous cystadenocarcinoma.