Surprisingly in human ACP samples, nucleo‐cytoplasmic accumulation of beta‐catenin and downstream activation of the pathway, as evidenced by expression of target genes (e.g. AXIN2), is mostly limited to only a small proportion of tumor cells, often correlating with epithelial whorls, sometimes referred to as “clusters”12, 22, 25, 27, 39. This evidence concerns the gene CTNNB1 and neoplasm.