RNF4 and infection: The capacity of EBV miR-BHRF1-1 to specifically target RNF4 was confirmed using luciferase reporters expressing wild type and mutant RNF4 3’UTR sequences, by expression of a synthetic miR-BHRF1-1 oligonucleotide or the inducible miRNA at levels comparable to those observed during productive infection, and, most importantly, by reversal of the phenotype upon selective inhibition of the endogenous miRNA in cells expressing an inducible miR-BHFR1-1 sponge.