Armeanet et al. identified a male with developmental delay and intellectual disability who carried an Xp11.22 deletion involving SHROOM4 and intellectual disability and autism has been described by Qiao et al. and De Wolf et al. in males carrying Xp11.22 deletions that included PHF8 and FAM120C [1,6,9]. This evidence concerns the gene SHROOM4 and Global developmental delay.