The combination of maternal HFD and MCD diet altered DNA methylation of EphB2 and VWF, whereas maternal HFD alone changed methylation of HNF4A, Ppargc1β and Fgf21. EphB2 has been recently shown to modulate hepatic fibrosis in several contexts [40] [41]. This evidence concerns the gene PPARGC1B and Hepatic fibrosis.