LDLR and myocardial infarction: Do et al. performed exome sequence analysis on patients with myocardial infarction and found that a set of non-synonymous mutations in the low-density lipoprotein receptor gene, with a total MAF of 1.3%, was associated with a 2.4-fold increased risk of myocardial infarction.[40] The mutation burden of the apolipoprotein A-V gene was also shown to be associated with a 2.0-fold increased risk of CAD, with a MAF of 0.46%.