Generally, the average copy number of FHIT in cervical cancer was decreased compared to that of CIN (Fig 3B, 1.43 to 0.98, P < 0.001), but not from normal cervical samples to CIN (Fig 3B, 1.51 to 1.43, P = 0.595). This evidence concerns the gene FHIT and cervical squamous intraepithelial neoplasia.