Depletion of CD8+ T cells resulted in a proportionate increase of MDSCs, mediating their suppressive functions on different immune cells by implementing co-ordinated function between several biomolecules, like, Arginase1, iNOS2, STAT3, MMP9, etc. Downregulation of MDSCs during the surgical removal of tumor before or after NLGP treatment correlates well with the downregulation of these suppressive molecules. This evidence concerns the gene MMP9 and neoplasm.