MMP9 and neoplasm: Expression of tumor-induced factors responsible for MDSCs’ differentiation and proliferation [39], such as, TGFβ, MMP9, IL-6, VEGF, CXCR4, CCL2 was upregulated in MDSCs from CD8 depleted NLGP immunized mice, that was in downregulation after NLGP treatment (Fig 3D).