TGFB1 and Hyperglycemia: Hyperglycemia has been demonstrated to incite podocyte EMT through several molecular mechanisms such as TGF-β/Smad classic pathway, Wnt/β-catenin signaling pathway, Integrins/ILK signaling pathway, RTK/Ras/Erk signaling pathway, MAPKs signaling pathway, PI3K/AKT/mTOR signaling pathway, Jagged/Notch signaling pathway, and NF-κB signaling pathway.3–7