It has been reported that modulating 5-HT signaling by administration of either fluoxetine or agonists of 5-HT receptors facilitates the recovery of locomotion after a spinal cord injury (SCI) in rodents (Courtine et al., 2009; Musienko et al., 2011; Scali et al., 2013). Here, HTR5A is linked to spinal cord injury.