MBP and myeloid sarcoma: Given the high prevalence of prior exposure and seropositivity (>90%) against HHV6 (Soldan et al., 1997) and EBV (Pender & Burrows, 2014) in the general population, and the existence of myelin‐reactive T cells in healthy individuals (Pette et al., 1990), we have therefore hypothesized that by using a biologically plausible candidate gene approach, that genetic variations in MBP may directly, or by interaction with HHV6 or EBV, determine clinical outcomes (conversion to MS after a first demyelinating event, relapse rate, and disability).