The differential expression of antiviral genes, like OAS2, RSAD2 and DDX58 (alias RIG1), that we observed in the small intestinal mucosa of piglets was also observed in weaned piglets fed with a high dose of zinc and challenged orally with the RNA virus TGEV, a virus causing diarrhoea in weaned piglets [12]. The gene discussed is OAS2; the disease is Diarrhea.