Furthermore, IPA analysis predicted effects on gastrointestinal diseases (P values of 6.25E−4–4.64E−13) and showed a strong enrichment in the upstream regulator HNF4a (P = 2.49E−6), a transcription factor known to be involved in gastrointestinal development (Additional file 4). This evidence concerns the gene HNF4A and gastrointestinal disease.