VLDLR is known to undergo ubiquitin-dependent endolysosomal degradation in response to Reelin signaling, where it controls PC migration.57, 59 Moreover, human mutations in VLDLR (MIM: 192977) are found in affected individuals with cerebellar ataxia and intellectual disability74 (MIM: 224050). This evidence concerns the gene RELN and aceruloplasminemia.