RELN and nervous system disorder: Interestingly, at the top of our unbiased total proteomic analysis of Plaa mutant cerebella were several proteins encoded by human neurological disease genes with phenotypes overlapping with PLAAND (4 out of the top 6: SNAP25 [MIM: 616330], VLDLR [MIM: 224050], AP4S1 [MIM: 614706], and GRN [MIM: 614706]), suggesting that Reelin signaling is unlikely to be the only signaling pathway disrupted upon PLAA reduction.