PRNP and glioblastoma: Therefore, this study aimed to elucidate the role of the HOP-PrPC complex in the regulation of GSCs by downregulating the expression of PrPC in a human GBM cell line cultured as GSCs and by testing how proliferation and self-renewal properties were affected in the presence of exogenous HOP; we also wished to evaluate the therapeutic potential of targeting this complex using synthetic peptides in attempt to alter GSC biology.