Conversely, aberrant overexpression of RUNX2 induced EMT-like changes in normal mammary glands and also caused cells to remain in a less-differentiated state with elevated expression of cyclin D1, a well-known PR-B (and other SRs) target gene and transcriptional co-regulator of phospho-PR at cancer-relevant PR-B/cyclin D1 target genes [98, 100]. Here, RB1 is linked to cancer.