ACSL3 and breast cancer: For the most part, expression of proteins involved in lipid droplet formation is increased in TNBC and basal-like breast cancers; however, certain proteins present in lipid droplets, such as ACSL3 and PLIN5, are underexpressed in TNBC, suggesting that there are different types of lipid droplets that might function to channel fatty acids to specific metabolic pathways.