CD274 and neoplasm: Considering the importance of both PD-L1 expression and CD8+ TILs in defining the tumor immune microenvironment [11–13], we co-assessed PD-L1 expression by immunohistochemistry and the density of CD8+ TILs in GC tissue samples and applied the scheme for TMIT classification based on PD-L1 expression/CD8 status.