PARP1 and neoplasm: Similar to a previous study [41] which showed that combination treatment with PARP inhibitor ABT888 (25 mg/kg) and irradiation (2 Gy) for 5 consecutive days delayed tumor growth in H460 xenograft model, our study showed combination treatment with LT626 (10 mg/kg and 20 mg/kg) with radiation (1 Gy) for 5 consecutive days was effective in decreasing the tumor burden and increasing overall survival.