GRN and neoplasm: According to the effects of PGRN derived from CRC cells on fibroblasts activation in this study, together with its roles in proliferation of CRC cells and stimulation of human umbilical vein endothelial cells (HUVECs) in our previous works [25], as well as other PGRN related studies in tumors, we proposed that PGRN should be treated as a pleiotropic pro-tumor molecule.