As various studies have demonstrated that the glycolytic enzyme HK is aberrantly expressed in GBM, where it is an important mediator of aerobic glycolysis, providing a proliferative and cell survival advantage [27] and knowing that VDAC1-based peptides interact with HK [16–20], the interaction of Tf-D-LP4 with HK was analyzed (Figure 2A). Here, HK1 is linked to glioblastoma.