RARA and T-cell non-Hodgkin lymphoma: To investigate the role of wild-type RARA (RARAwt) and RARAR394Q, we utilized three mature T-cell lymphoma cell lines (see Materials and Methods) with varied native RARA expression: one RARAhigh cell line (Mac-1) and two RARAlow cell lines (Karpas 299 and HuT78; Figure 1A).