There are 11 pathways that are shared between the tumor and adjacent tissues (Table 4), which include the neuroactive ligand-receptor interaction, the ABC transporters, the calcium signaling pathway, the phosphatidylinositol signaling system, the GnRH signaling, the hematopoietic cell lineage, the focal adhesion and the gap junction pathways. This evidence concerns the gene GNRH1 and neoplasm.