In addition, we found that the L104P mutation in the VCX gene (Variable charge, X-linked) was detected with increasing frequencies from the normal, the adjacent tissues to the tumor tissues—frequencies of 14.6% in the HCC tissues, 11.1% in the adjacent tissues, and absent (0%) in the white blood cell samples (Supplementary Table 8), suggesting that this mutation might be a tumor driver gene driving HCC carcinogenesis. The gene discussed is VCX; the disease is neoplasm.