KMT2A and acute myeloid leukemia: We found that ZNF521 was expressed at significantly higher level in AML patients with MLL rearrangements compared to non-rearranged AML and normal controls (P < 0.001, Figure 1A), The analysis of ZNF521 expression between the most frequent MLL rearrangements detected in pediatric AML did not reveal significant difference based on MLL fusion partners (data not shown).