The chr20 region (chr20p12.1) affects a relatively quiescent interval and a protein-coding gene expressed at low levels in iPSCs: MACROD2 (MACRO Domain Containing 2), a gene involved in autism (Jones et al., 2014) and in tamoxifen resistance in breast cancer (Mohseni et al., 2014). This evidence concerns the gene MACROD2 and breast carcinoma.