As observed in our previous study, which investigated the effects of low glucose conditions in PCa cell lines, a number of proteins that play a role in the adaptive metabolic response of cancer cells to the tumour microenvironment were among those with a significant change in expression between androgen sensitive (LNCaP) and the androgen independent (Abl and Hof) cell lines. This evidence concerns the gene ABL1 and posterior cortical atrophy.