Decreased expression of CYFIP1 has been reported in some cancers, such as colon breast or bladder cancer [21].The mRNA expression analysis in epidermis from cutaneous SCC samples showed reduced mRNA expression in tumors compared to the epidermis of normal skin (Fig 1A; normal epidermis: mean 0.011, SD ± 0.0059; SCC: mean 0.0069, SD ± 0.0027; p = 0.034). The gene discussed is CYFIP1; the disease is urinary bladder cancer.