Our analysis of CYFIP1 expression in well-, moderately- and poorly-differentiated squamous cell carcinomas showed down-regulated CYFIP1 expression in line with a loss of differentiation in tumor cells, suggesting a possible mechanism linking the loss of histological differentiation to increased invasive potential, a phenomenon observed also in other tumors such as esophagus, prostate, colon and breast[34–38]. Here, CYFIP1 is linked to squamous cell carcinoma.