IL10RA and neoplasm: However, since OC metastases are generally restricted to the peritoneal cavity even in late clinical stages, an i.p. administration of IL-10-specific antibodies or IL-10R blockers may hold promise and may be an approach worth exploring in in vivo models of murine OC where IL-10 signalling has also been shown to be of central importance to the regulation of immune responses within the tumour environment [32].