In anti-GBM patients without MPO-ANCA, the patients having P1-IgG showed higher serum creatinine (800.0, 437.5–1500 vs. 312.8, 216.1–564.8μmol/L, P = 0.009) compared to those without P1-IgG (Fig 2A). This evidence concerns the gene MPO and glioblastoma.