SPRY4 and neoplasm: As shown in Table 3, the meta-analysis results showed that the SPRY4-IT1 expression level was not correlated with the clinicopathological parameters including age (P = 0.37, Supplementary Figure 4), gender (P = 0.87, Supplementary Figure 5), tumor size (P = 0.47, Supplementary Figure 6) and invasion depth (P = 0.52, Supplementary Figure 7).