SPRY4 and central nervous system cancer: In the aspect of the prognostic role of SPRY4-IT1, the increased expression of SPRY4-IT1 was closely associated with poor prognosis in various types of cancers including bladder cancer, cervical cancer, colorectal cancer, ESCC, gastric cancer, glioma, melanoma, NSCLC and RCC [6, 11–13, 16, 18, 22–25].