SPRY4 and neoplasm: However, the meta-analysis showed that the increased SPRY4-IT1 expression level was significantly associated with distant metastasis (odds ratio (OR) = 1.96, 95% CI: 1.24-3.08, P = 0.004, Supplementary Figure 8), lymph node metastasis (OR = 3.96, 95% CI: 1.48-5.54, P<0.001, Supplementary Figure 9), advanced tumor/node/metastasis (TNM) stage (OR = 3.72, 95% CI = 2.91-4.76, P<0.001, Supplementary Figure 10), and poor tumor differentiation (OR = 1.86, 95% CI = 1.35-2.58, P<0.001, Supplementary Figure 11).