CYSLTR1 and malignant colon neoplasm: We have also shown that the LTD4-induced CysLT1R signaling is important in promoting colorectal tumorigenesis by increasing the expression of proteins associated with cell survival (COX-2 and Cyclin D1) and increased proliferation and migration (β-catenin) in xenograft colon cancer and colon cancer cell lines [18–20].