In our AOM/DSS mouse model, the colonic polyps of Cysltr1−/− mice displayed decreased protein and mRNA expression of COX-2 and 5-LOX, with increased mRNA levels of the tumor suppressor 15-PGDH [30], which together imply a better outcome, even though no difference was seen in colonic CysLT2 receptor expression between vehicle control and AOM/DSS treated wild type or Cysltr1−/− mice (Supplementary Figure 1). Here, HPGD is linked to infectious otitis media.