Figure 2A showing vehicle control normal areas stained with hematoxylin and eosin (H&E) Cysltr1−/− mice and their wild-type counterparts (Cysltr1+/+), The AOM/DSS treatment induced dysplastic lesions/aberrant crypt foci (ACF) in the mouse colons, and H&E staining revealed that the wild-type polyps were serrated adenomatous structures, while the Cysltr1−/− polyps were low-grade dysplastic in nature (Figure 2B). The gene discussed is CYSLTR1; the disease is infectious otitis media.