In the ApcMin/+ mouse model, the loss of function of the tumor suppressor gene Adenomatous polyposis coli (Apc) is an early event in tumorigenesis, which is consistent with autosomal dominant inherited colorectal cancer (familial adenomatous polyposis; FAP) and sporadic colorectal cancer [22, 23]. Here, APC is linked to Familial adenomatous polyposis.