ALOX5 and colonic neoplasm: Colon cancer development has been shown to be promoted by the irregular metabolism of arachidonic acid, an ω-6 family of polyunsaturated essential fatty acids, which ultimately leads to the generation of the proinflammatory lipid mediators prostaglandins and leukotrienes via cyclooxygenase (COX) isozymes 1 and 2 and 5-lipoxygenase (5-LOX), respectively [5].