FLI1, as an Ets family member of transcription factors, was identified as a proto-oncogene in other tumors through the regulation of different target genes, including upregulation of Bcl-2 to inhibit apoptosis in tumor cells, transcriptional downregulation of gata-1 and RB1 to inhibit erythroid differentiation, and direct upregulation of MDM2 to destabilize the anti-apoptotic protein TP53 in tumor progression [23–26]. This evidence concerns the gene GATA1 and neoplasm.