To examine the impact of FLI1 on biological behavior of SCLC, we used two small interference RNAs (siFLI 1# and siFLI 2#) to knockdown FLI1 in NCI-H446 cells that express abundant FLI1. Efficient knockdown of FLI1 was verified by Western blot (Figure 2A). The gene discussed is FLI1; the disease is small cell lung carcinoma.