Further immunohistochemistry analysis of the tumor tissues from the subcutaneous xenografts revealed that the levels of PLOD2, snail and β-catenin were significantly lower in xenografts of sh-PLOD2 cells than in xenografts of sh-con cells while E-cadherin was markedly upregulated in xenografts of sh-PLOD2 cells, consistent with our in vitro findings (Figure 5). Here, PLOD2 is linked to neoplasm.