For examples, circHIPK3 regulates cell growth by sponging multiple miRNAs [13]; circITCH plays an inhibitory role in esophageal squamous cell carcinoma (ESCC) by suppressing the Wnt/β-catenin pathway through interacting with multiple miRNAs [14]; Cdr1 antisense locus (CDR1as) acts as an oncogene partly through targeting miR-7 in HCC [15]. This evidence concerns the gene CDR1 and esophageal squamous cell carcinoma.